Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …

Untargeted metabolomics is the study of all detectable small molecules, and in geroscience,
metabolomics has shown great potential to describe the biological age—a complex trait …

It is reported that overweight may lead to accelerated aging. However, there is still a lack of
evidence on the causal effect of overweight and aging. We collected genetic variants …

Diet contributes to health at all stages of life, from embryonic development to old age.
Nutrients, including vitamins, amino acids, lipids and sugars, have instructive roles in …

Aging is a major risk factor for many diseases. Accurate methods for predicting age in
specific cell types are essential to understand the heterogeneity of aging and to assess …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …

Metabolomics, the global profiling of small molecules in the body, has emerged as a
promising analytical approach for assessing molecular changes associated with ageing at …