During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Gamete (sperm and oocyte) genomes are transcriptionally silent until embryonic genome
activation (EGA) following fertilization. EGA in humans had been thought to occur around the …

Abstract Poly (A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in
the oocyte-to-embryo transition (OET). Nothing is known about poly (A) tail dynamics during …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

Accurate chromosome segregation during meiosis is crucial for reproduction. Human and
porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

LINE-1s are the major clade of retrotransposons with autonomous retrotransposition activity.
Despite the potential genotoxicity, LINE-1s are highly activated in early embryos. Here we …

Background Oocyte maturation arrest and early embryonic arrest are important reproductive
phenotypes resulting in female infertility and cause the recurrent failure of assisted …

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …

Although parental genomes undergo extensive epigenetic reprogramming to be equalized
after fertilization, whether they play different roles in human zygotic genome activation (ZGA) …