In vitro and in vivo efficacy of naturally derived scaffolds for cartilage repair and regeneration

V Thomas, J Mercuri - Acta Biomaterialia, 2023 - Elsevier
Intrinsically present bioactive cues allow naturally derived materials to mimic important
characteristics of cartilage while also facilitating cellular recruitment, infiltration, and …

[HTML][HTML] Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere

R Pinto-Cardoso, C Bessa-Andrês… - Biochemical …, 2023 - Elsevier
The osteochondral unit comprises the articular cartilage (90%), subchondral bone (5%) and
calcified cartilage (5%). All cells present at the osteochondral unit that is ultimately …

Hydrogels as a Growth Factor-Free Strategy for Cartilage Tissue Engineering

T Roncada, G Blunn, M Roldo - 2023 - preprints.org
Focal cartilage defects are a prevalent knee problem affecting people of all ages. Due to its
avascular nature, cartilage has limited self-repair capacity, and osteochondral defects can …

Structure-related effects of pentosan polysulfate sodium: modulation on phenotypic change and chondrogenic properties in canine chondrocyte in-vitro cultures

王延璘 - 2023 - eprints.lib.hokudai.ac.jp
Hyaline cartilage is a specialized connective tissue on the joint surface that supports normal
joint movements and protects the subchondral bone. Chondrocytes are the only cellular …

Sulfate level relied effects of pentosan polysulfate sodium on inhibiting the proliferation of canine articular chondrocytes by targeting PI3K/Akt pathway

Y Wang, C Mwale, E Akaraphutiporn, S Kim… - Japanese Journal of …, 2023 - jstage.jst.go.jp
Articular chondrocytes experience a transient increase in proliferation and subsequent loss
of chondrogenic phenotype in the early stage of osteoarthritis (OA). Pentosan polysulfate …