Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …

Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its
immune-oncology pipeline over the last years. This is in great part due to the recent …

Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic
receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv …

Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Efforts to treat cancer using chimeric antigen receptor (CAR)-T therapy have made
astonishing progress and clinical trials against hematopoietic malignancies have …

Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the management of
several life-threatening malignancies, often achieving durable sustained responses. The …

By analyzing patients treated with adoptive immune cell therapies, various immune cell
phenotypes have been found in the starting and infused materials as determinants of …

Enzyme‐instructed self‐assembly of bioactive molecules into nanobundles inside cells is
conceived to potentially disrupt plasma membrane and subcellular structure. Herein, an …

Chimeric antigen receptor (CAR) T cell immunotherapy is emerging as a powerful tool for
cancer treatment. However, the clinical application of CAR T cell therapy remains limited …