Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

Inflammasomes are one kind of important innate immune defense against viral and bacterial
infections. Several inflammasome-forming sensors detect molecular patterns of invading …

Licorice, a natural medicine derived from the roots and rhizomes of Glycyrrhiza species,
possesses a wide range of therapeutic applications, including antiviral properties …

Re-emerging and new viral pathogens have caused significant morbidity and mortality
around the world, as evidenced by the recent monkeypox, Ebola and Zika virus outbreaks …

This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that
manifests under diverse and divergent circumstances. We begin with a historical …

Gammaherpesviruses, including Kaposi sarcoma-associated herpesvirus (KSHV) and
Epstein-Barr virus (EBV), are DNA viruses that are globally associated with human cancers …

The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity.
Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family …

Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …

Cyclic GMP-AMP synthase (cGAS) recognizes viral DNA and synthesizes cyclic GMP-AMP
(cGAMP), which activates stimulator of interferon genes (STING/MITA) and downstream …