An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Musculoskeletal aging encompasses the decline in bone and muscle function, leading to
conditions such as frailty, osteoporosis, and sarcopenia. Unraveling the underlying …

Recent work has established associations between elevated p21, the accumulation of
senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse …

Cells can irreversibly exit the cell cycle and become senescent to safeguard against
uncontrolled proliferation. While the p53-p21 and p16-Rb pathways are thought to mediate …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

A gradual decline in skeletal muscle mass and function is closely tied to increased mortality
and disease risk during organismal aging. Exercise training is the most effective way to …

Chromosomal instability (CIN) is a pervasive feature of human cancers involved in tumor
initiation and progression and which is found elevated in metastatic stages. CIN can provide …

Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase
governing spindle assembly checkpoint activation and sister chromatid separation in …

Increased ovarian fibrosis and an expanded stromal cell compartment are the main
characteristics of aging ovaries. However, the molecular mechanisms and the key factor of …

This review investigates the role of aneuploidy and chromosome instability (CIN) in the
aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the …