Stem cell-based strategies and challenges for production of cultivated meat

TC Jara, K Park, P Vahmani, AL Van Eenennaam… - Nature Food, 2023 - nature.com
Cultivated meat scale-up and industrial production will require multiple stable cell lines from
different species to recreate the organoleptic and nutritional properties of meat from …

[HTML][HTML] Organization of the human intestine at single-cell resolution

JW Hickey, WR Becker, SA Nevins, A Horning… - Nature, 2023 - nature.com
The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

[HTML][HTML] The role of PPARγ in prostate cancer development and progression

A Hartley, I Ahmad - British Journal of Cancer, 2023 - nature.com
Advanced and metastatic prostate cancer is often incurable, but its dependency on certain
molecular alterations may provide the basis for targeted therapies. A growing body of …

[HTML][HTML] Effects of bacteriophage on Salmonella Enteritidis infection in broilers

Z Sarrami, M Sedghi, I Mohammadi, M Bedford… - Scientific Reports, 2023 - nature.com
Bacteriophages (BP) are viruses that can infect bacteria. The present study evaluated the
effect of BP on Salmonella infected broilers. A number of 150 day-old broilers were used in a …

[HTML][HTML] A PPARγ/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice

Z Zhang, Y Cui, V Su, D Wang, MJ Tol… - The Journal of …, 2023 - Am Soc Clin Investig
Interplay between energy-storing white adipose cells and thermogenic beige adipocytes
contributes to obesity and insulin resistance. Irrespective of specialized niche, adipocytes …

[HTML][HTML] Collagens regulating adipose tissue formation and functions

I Jääskeläinen, T Petäistö, E Mirzarazi Dahagi… - Biomedicines, 2023 - mdpi.com
The globally increasing prevalence of obesity is associated with the development of
metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose …

Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and HCC

A Smiriglia, N Lorito, M Serra, A Perra, A Morandi… - Iscience, 2023 - cell.com
Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …

[HTML][HTML] Lipid nanoparticles as a shuttle for anti-adipogenic miRNAs to human adipocytes

AL Schachner-Nedherer, J Fuchs, I Vidakovic, O Höller… - Pharmaceutics, 2023 - mdpi.com
Obesity and type 2 diabetes are major health burdens for which no effective therapy is
available today. One treatment strategy could be to balance the metabolic functions of …

[HTML][HTML] HSP47 levels determine the degree of body adiposity

J Shin, S Toyoda, Y Okuno, R Hayashi… - Nature …, 2023 - nature.com
Adiposity varies among individuals with the influence of diverse physiological, pathological,
environmental, hormonal, and genetic factors, but a unified molecular basis remains elusive …

Peroxisome proliferator-activated receptors: A key link between lipid metabolism and cancer progression

Y Li, Y Pan, X Zhao, S Wu, F Li, Y Wang, B Liu… - Clinical Nutrition, 2023 - Elsevier
Lipids represent the essential components of membranes, serve as fuels for high-energy
processes, and play crucial roles in signaling and cellular function. One of the key hallmarks …