Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …

Widespread sequencing has yielded thousands of missense variants predicted or confirmed
as disease-causing. This creates a new bottleneck: determining the functional impact of …

The rapid evolution of protein structure prediction tools has significantly broadened access
to protein structural data. Although predicted structure models have the potential to …

Until recently, efforts in population genetics have been focused primarily on people of
European ancestry. To attenuate this bias, global population studies, such as the 1000 …

Intrinsically disordered regions (IDRs) are protein regions that are unable to fold into stable
tertiary structures, enabling their involvement in key signaling and regulatory functions via …

Genetics is an important factor determining the predisposition to the development of many
diseases and influencing the overall life expectancy of a person. We have already discussed …

Human genome sequencing studies have identified numerous loci associated with complex
diseases. However, translating human genetic and genomic findings to disease …

Introduction: Somatic mutations in cancer are caused by a complex interaction of many
starting and driving factors that work together to create a unique mutational landscape …

Anomalies in protein–protein interactions may lead to a diseased state, as many cellular
functions are sustained by such interactions. These abnormal situations usually arise when …

This chapter focuses on the main new drug development strategies using the fragment-
based drug design (FBDD) approach and its relationship with high-throughput screening …