Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Recent studies proposed a general psychopathology factor underlying common
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Tourette syndrome is a chronic neurodevelopmental disorder characterised by motor and
phonic tics that can substantially diminish the quality of life of affected individuals. Evaluating …

Evolutionary biology provides a crucial foundation for medicine and behavioral science that
has been missing from psychiatry. Its absence helps to explain slow progress; its advent …