The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

Carbapenem resistance mediated by metallo-β-lactamases (MBL) such as New Delhi
metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of …

New Delhi metallo-β-lactamase-1 (NDM-1) poses a threat to public health due to its
capability to hydrolyze nearly all β-lactam antibiotics, leaving limited treatment options for …

The upswing of antibiotic resistance is an escalating threat to human health. Resistance
mediated by bacterial metallo-β-lactamases is of particular concern as these enzymes …

Beta-lactam antibiotics are one of the most commonly used drug classes in managing
bacterial infections. However, their use is threatened by the alarming phenomenon of …

Background Carbapenemase-producing makes a great contribution to carbapenem
resistance in Gram-negative bacilli. Bla AFM-1 gene was first discovered by us in …

Mutations can have deleterious fitness effects when they decrease protein specific activity or
decrease active protein abundance. Mutations will also be deleterious when they cause …

The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been
impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …

A practical electrochemical method for the determination of the inhibitory activity of New
Delhi metallo-β-lactamase-1 (NDM-1) inhibitors was established with a bare pencil graphite …

Abstract Pseudomonas aeruginosa is a pathogenic and nosocomial bacterium responsible
for serious healthcare-associated infections mainly for its resistance to antibiotics. Against …