Y Jia, B Schroeder, Y Pfeifer, C Fröhlich… - Journal of Medicinal …, 2023 - ACS Publications
Carbapenem resistance mediated by metallo-β-lactamases (MBL) such as New Delhi metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of …
H Lv, Z Zhu, C Qian, T Li, Z Han, W Zhang, X Si… - Biomedicine & …, 2023 - Elsevier
New Delhi metallo-β-lactamase-1 (NDM-1) poses a threat to public health due to its capability to hydrolyze nearly all β-lactam antibiotics, leaving limited treatment options for …
K Palica, F Deufel, S Skagseth… - RSC Medicinal …, 2023 - pubs.rsc.org
The upswing of antibiotic resistance is an escalating threat to human health. Resistance mediated by bacterial metallo-β-lactamases is of particular concern as these enzymes …
N Bognanni, F Brisdelli, A Piccirilli, L Basile… - Journal of Inorganic …, 2023 - Elsevier
Beta-lactam antibiotics are one of the most commonly used drug classes in managing bacterial infections. However, their use is threatened by the alarming phenomenon of …
Y Qin, Y Peng, X Duan, Z Song, R Huang… - Annals of Clinical …, 2023 - Springer
Background Carbapenemase-producing makes a great contribution to carbapenem resistance in Gram-negative bacilli. Bla AFM-1 gene was first discovered by us in …
Mutations can have deleterious fitness effects when they decrease protein specific activity or decrease active protein abundance. Mutations will also be deleterious when they cause …
The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …
H Gan, Y Liang, Y Tang, M Huang, Y Wan - Microchemical Journal, 2023 - Elsevier
A practical electrochemical method for the determination of the inhibitory activity of New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors was established with a bare pencil graphite …
Abstract Pseudomonas aeruginosa is a pathogenic and nosocomial bacterium responsible for serious healthcare-associated infections mainly for its resistance to antibiotics. Against …