Bioenergetics: the evolutionary basis of progressive kidney disease

RL Chevalier - Physiological Reviews, 2023 - journals.physiology.org
Chronic kidney disease (CKD) affects> 10% of the world population, with increasing
prevalence in middle age. The risk for CKD is dependent on the number of functioning …

Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development

A Sur, Y Wang, P Capar, G Margolin, MK Prochaska… - Developmental Cell, 2023 - cell.com
During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

Insights into human kidney function from the study of Drosophila

S Koehler, TB Huber - Pediatric Nephrology, 2023 - Springer
Biological and biomedical research using Drosophila melanogaster as a model organism
has gained recognition through several Nobel prizes within the last 100 years. Drosophila …

Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells

Y Rbaibi, KR Long, KE Shipman, Q Ren… - Molecular Biology of …, 2023 - Am Soc Cell Biol
The kidney proximal tubule (PT) elaborates a uniquely high-capacity apical endocytic
pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier …

Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs

SK Han, MT McNulty, CJ Benway, P Wen… - Nature …, 2023 - nature.com
Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate
specific genes and contribute to fine-mapped loci discovered via genome-wide association …

Single-cell profiling of the developing embryonic heart in Drosophila

X Huang, Y Fu, H Lee, Y Zhao, W Yang… - …, 2023 - journals.biologists.com
Drosophila is an important model for studying heart development and disease. Yet, single-
cell transcriptomic data of its developing heart have not been performed. Here, we report …

Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis

A Patir, A Raper, R Fleming… - G3: Genes …, 2023 - academic.oup.com
It is estimated that animals pollinate 87.5% of flowering plants worldwide and that managed
honey bees (Apis mellifera) account for 30–50% of this ecosystem service to agriculture. In …

Honey Bee Larval Hemolymph as a Source of Key Nutrients and Proteins Offers a Promising Medium for Varroa destructor Artificial Rearing

V Piou, C Vilarem, S Blanchard, JM Strub… - International Journal of …, 2023 - mdpi.com
Varroa destructor, a major ectoparasite of the Western honey bee Apis mellifera, is a
widespread pest that damages colonies in the Northern Hemisphere. Throughout their …

The model of the fruit fly Drosophila melanogaster as a novel tool for characterization of human membrane transporters

J Yang - 2023 - ub01.uni-tuebingen.de
Numerous studies have demonstrated that membrane transporters are critical determinants
for drug disposition, drug absorption, therapeutic efficacy, and adverse drug reactions. In the …