Primary aldosteronism: molecular medicine meets public health

EAB Azizan, WM Drake, MJ Brown - Nature Reviews Nephrology, 2023 - nature.com
Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice

R Lyraki, A Grabek, A Tison… - Disease Models & …, 2023 - journals.biologists.com
Female bias is highly prevalent in conditions such as adrenal cortex hyperplasia and
neoplasia, but the reasons behind this phenomenon are poorly understood. In this study, we …

The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6

ZT Spencer, VH Ng, H Benchabane… - Nature …, 2023 - nature.com
The control of Wnt receptor abundance is critical for animal development and to prevent
tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We …

[HTML][HTML] An integrated single-cell analysis of human adrenal cortex development

I Del Valle, MD Young, G Kildisiute, OK Ogunbiyi… - JCI insight, 2023 - ncbi.nlm.nih.gov
The adrenal glands synthesize and release essential steroid hormones such as cortisol and
aldosterone, but many aspects of human adrenal gland development are not well …

Post‐hatching developmental changes in the adrenal gland of the Japanese quail (Coturnix coturnix japonica): Histological, immunohistochemical, and electron …

FM Abdel‐maksoud, S Fadl… - Microscopy …, 2023 - Wiley Online Library
The adrenal glands are paired abdominal endocrine organs vital to the bird's health. The
present research aimed to provide a comprehensive examination of the histological …

Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

AV Kurtova, M Heinlein, S Haas, L Velten… - Blood …, 2023 - ashpublications.org
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure
tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues …

[图书][B] Genetic steroid disorders

MI New, B O'Malley, GD Hammer, O Lekarev, A Parsa… - 2023 - books.google.com
Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists,
clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists …

Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation

C Lucas, KS Sauter, M Steigert, D Mallet… - The journal of …, 2023 - Am Soc Clin Investig
Disorders of isolated mineralocorticoid deficiency, which cause potentially life-threatening
salt-wasting crisis early in life, have been associated with gene variants of aldosterone …

In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland

R Fu, K Walters, ML Kaufman, K Koc… - Journal of the …, 2023 - academic.oup.com
The human adrenal gland consists of concentrically organized, functionally distinct regions
responsible for hormone production. Dysregulation of adrenocortical cell differentiation …

Changes in Rat Adrenal Cortex and Pineal Gland in Inverted Light–Dark Cycle: A Biochemical, Histological, and Immunohistochemical Study

HA Shawky, SMN Abdel Hafez… - Microscopy and …, 2023 - academic.oup.com
Poor sleep standards are common in everyday life; it is frequently linked to a rise in stress
levels. The adrenal gland interacts physiologically with the pineal gland in the stress …