[HTML][HTML] The neuroprotective activities of the novel multi-target iron-chelators in models of Alzheimer's disease, amyotrophic lateral sclerosis and aging

L Kupershmidt, MBH Youdim - Cells, 2023 - mdpi.com
The concept of chelation therapy as a valuable therapeutic approach in neurological
disorders led us to develop multi-target, non-toxic, lipophilic, brain-permeable compounds …

[HTML][HTML] Oxygen metabolism abnormality and Alzheimer's disease: An update

G Liu, C Yang, X Wang, X Chen, Y Wang, W Le - Redox Biology, 2023 - Elsevier
Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

[HTML][HTML] TCMBank: bridges between the largest herbal medicines, chemical ingredients, target proteins, and associated diseases with intelligence text mining

Q Lv, G Chen, H He, Z Yang, L Zhao, HY Chen… - Chemical …, 2023 - pubs.rsc.org
Traditional Chinese Medicine (TCM) has long been viewed as a precious source of modern
drug discovery. AI-assisted drug discovery (AIDD) has been investigated extensively …

Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD

J Wang, P Chen, B Hu, F Cai, Q Xu, S Pan… - The FASEB …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and Parkinson's disease (PD) are age‐dependent
neurodegenerative disorders. There is a profound neuronal loss in the basal forebrain …