Gone Too Soon: priorities for action to prevent premature mortality associated with mental illness and mental distress

RC O'Connor, CM Worthman, M Abanga… - The Lancet …, 2023 - thelancet.com
Globally, too many people die prematurely from suicide and the physical comorbidities
associated with mental illness and mental distress. The purpose of this Review is to mobilise …

[HTML][HTML] How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide

X Gonda, P Dome, G Serafini, M Pompili - Pharmacology & Therapeutics, 2023 - Elsevier
The impact of suicide on our societies, mental healthcare, and public health is beyond
questionable. Every year approximately 700 000 lives are lost due to suicide around the …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors

AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …

[HTML][HTML] Genome-wide association study meta-analysis of suicide death and suicidal behavior

QS Li, AA Shabalin, E DiBlasi, S Gopal… - Molecular …, 2023 - nature.com
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …

[HTML][HTML] Shared genetic liability for alcohol consumption, alcohol problems, and suicide attempt: Evaluating the role of impulsivity

M Stephenson, S Lannoy, AC Edwards - Translational psychiatry, 2023 - nature.com
Heavy drinking and diagnosis with alcohol use disorder (AUD) are consistently associated
with risk for suicide attempt (SA). Though the shared genetic architecture among alcohol …

Identification of novel, replicable genetic risk loci for suicidal thoughts and behaviors among US military veterans

NA Kimbrel, AE Ashley-Koch, XJ Qin… - JAMA …, 2023 - jamanetwork.com
Importance Suicide is a leading cause of death; however, the molecular genetic basis of
suicidal thoughts and behaviors (SITB) remains unknown. Objective To identify novel …

Suicidal behavior across a broad range of psychiatric disorders

YE Xu, DA Barron, K Sudol, S Zisook… - Molecular …, 2023 - nature.com
Suicide is a leading cause of death worldwide. In 2020, some 12.2 million Americans
seriously contemplated suicide, 3.2 million planned suicide attempts, and 1.2 million …

[HTML][HTML] Biological factors underpinning suicidal behaviour: an update

MN Abou Chahla, MI Khalil, S Comai, L Brundin… - Brain sciences, 2023 - mdpi.com
Suicide, a global health burden, represents the 17th leading cause of death worldwide
(1.3%), but the 4th among young people aged between 15 and 29 years of age, according to …

Gene copy number variation and pediatric mental health/neurodevelopment in a general population

M Zarrei, CL Burton, W Engchuan… - Human Molecular …, 2023 - academic.oup.com
We assessed the relationship of gene copy number variation (CNV) in mental health/
neurodevelopmental traits and diagnoses, physical health and cognition in a community …