Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Sarcopenia is a common skeletal muscle disorder, characterised by a loss of muscle mass
and impaired muscle function, that is associated with poorer health outcomes. While …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …

Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Socio-economic status (SES) and biological aging are risk factors for dementia, including
Alzheimer's disease, however, it is less clear if the associations with SES vary sufficiently …

Biological age (BA) is a common model to evaluate the function of aging individuals as it
may provide a more accurate measure of the extent of human aging than chronological age …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Biological age captures a person's age-related risk of unfavorable outcomes using
biophysiological information. Multivariate biological age measures include frailty scores and …