Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote …

P Fang, C Xie, T Pan, T Cheng, W Chen… - Nucleic Acids …, 2023 - academic.oup.com
Abstract G-quadruplex (G4) is a unique secondary structure formed by guanine-rich nucleic
acid sequences. Growing studies reported that the genomes of some viruses harbor G4 …

Diversity for endoribonuclease nsp15-mediated regulation of alpha-coronavirus propagation and virulence

Y Xie, C Chen, D Zhang, Z Jiao, Y Chen… - Microbiology …, 2023 - Am Soc Microbiol
Endoribonuclease non-structural protein 15 (nsp15)(EndoU) is conserved among
coronaviruses (CoVs) and is crucial for viral replication, evasion of the innate immune …

PCNA promotes PRRSV replication by increasing the synthesis of viral genome

Q Wang, H Yi, Y Guo, Y Sun, Z Yu, L Lu, R Ye… - Veterinary …, 2023 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus belonging to
the Arteriviridae family. Currently, the strain has undergone numerous mutations, bringing …