Single-cell multiomics
E Flynn, A Almonte-Loya… - Annual Review of …, 2023 - annualreviews.org
Single-cell RNA sequencing methods have led to improved understanding of the
heterogeneity and transcriptomic states present in complex biological systems. Recently, the …
heterogeneity and transcriptomic states present in complex biological systems. Recently, the …
An atlas of healthy and injured cell states and niches in the human kidney
Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
[PDF][PDF] hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …
functional units based on tightly regulated interactions between distinct molecules, cells …
The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
The transcriptional landscape of plant infection by the rice blast fungus Magnaporthe oryzae reveals distinct families of temporally co-regulated and structurally …
The rice blast fungus Magnaporthe oryzae causes a devastating disease that threatens
global rice (Oryza sativa) production. Despite intense study, the biology of plant tissue …
global rice (Oryza sativa) production. Despite intense study, the biology of plant tissue …
Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models
P Mews, AM Cunningham, J Scarpa… - Science …, 2023 - science.org
Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates
represent a substantial public health crisis that exacts tremendous personal and financial …
represent a substantial public health crisis that exacts tremendous personal and financial …
Dissecting cell identity via network inference and in silico gene perturbation
Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …
Prioritization of potential causative genes for schizophrenia in placenta
Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …
complications in affecting risk for the disorder and sex-biased neurodevelopmental …
Quality control and removal of technical variation of NMR metabolic biomarker data in~ 120,000 UK Biobank participants
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in
approximately 121,000 UK Biobank participants has recently been released as a community …
approximately 121,000 UK Biobank participants has recently been released as a community …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …