Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic
inflammatory diseases, can increase tumor incidence and promote tumor growth and …

Background Cancer is a major burden of disease worldwide and increasing evidence shows
that inflammation contributes to cancer development and progression. Eicosanoids are …

Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …

Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key
biological processes. The complexity of cancer pathogenesis is best illustrated in the six …

Diabetes is a common chronic metabolic disease, and its incidence continues to increase
year after year. Diabetic patients mainly die from various complications, with the most …

Cancer immunotherapy targeting myeloid-derived suppressor cells (MDSCs) is one of the
most promising anticancer strategies. Metabolic reprogramming is vital for MDSC activation …

Colorectal cancer (CRC) is the second leading cause of tumor-related deaths worldwide.
Resistance of tumor cells to drug-induced apoptosis highlights the need for safe and …

Abstract Oncoprotein-induced transcript 3 (OIT3) facilitates macrophage M2 polarization and
hepatocellular carcinoma (HCC) progression, however, whether OIT3 regulates tumor …

Background Myeloid-derived suppressor cells (MDSCs) are crucial mediators of tumor-
associated immune suppression. Targeting the accumulation and activation of MDSCs has …