Towards a youth mental health paradigm: a perspective and roadmap
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …
and progression and have potential to produce clinically useful biomarkers. A growing body …
A transdiagnostic network for psychiatric illness derived from atrophy and lesions
Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used …
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used …
A review of approaches and models in psychopathology conceptualization research
Mental disorder classification provides a definitional framework that underlies applied
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …
[HTML][HTML] Major depression and the biological hallmarks of aging
Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …
manifestations contributing to the disease severity and outcome. In recent years, several …
Association of childhood externalizing, internalizing, and comorbid symptoms with long-term economic and social outcomes
Importance Little is known about the long-term economic and social outcomes for children
with longitudinally assessed comorbid externalizing and internalizing symptoms, especially …
with longitudinally assessed comorbid externalizing and internalizing symptoms, especially …
Complexity theory of psychopathology.
There is a renewed interest for complex adaptive system approaches that can account for
the inherently complex and dynamic nature of psychopathology. Yet a theory of …
the inherently complex and dynamic nature of psychopathology. Yet a theory of …
Annual Research Review: Stability of psychopathology: lessons learned from longitudinal population surveys
AJ Oldehinkel, J Ormel - Journal of Child Psychology and …, 2023 - Wiley Online Library
Background Psychopathology has been long recognized as a fluctuating process with
various expressions over time, which can only be properly understood if we follow …
various expressions over time, which can only be properly understood if we follow …
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …
Transdiagnostic risk of mental disorders in offspring of affected parents: a meta‐analysis of family high‐risk and registry studies
The offspring of parents with mental disorders are at increased risk for developing mental
disorders themselves. The risk to offspring may extend transdiagnostically to disorders other …
disorders themselves. The risk to offspring may extend transdiagnostically to disorders other …