The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Importance Cancers are a leading cause of mortality, accounting for nearly 10 million annual
deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries' economic …

Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …

Background Cancer has been the leading cause of death since 2010 in China, with
increasing incidence, mortality, and burden. We aimed to assess national and subnational …

Abstract Background The triglyceride-glucose (TyG) index and triglyceride to high-density
lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin …

Abstract Background The American Heart Association recently updated its construct of what
constitutes cardiovascular health (CVH), called Life's Essential 8. We examined the …

Background: We projected global trends in ischemic stroke from 2020 to 2030 according to
age, sex, and socio-demographic index (SDI) quintile. Methods: Estimated annual …

Background Although meningitis is largely preventable, it still causes hundreds of thousands
of deaths globally each year. WHO set ambitious goals to reduce meningitis cases by 2030 …

Background Peripheral artery disease is a growing public health problem. We aimed to
estimate the global disease burden of peripheral artery disease, its risk factors, and …