T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

Since the original description of spondyloarthritis 50 years ago, results have demonstrated
similarities and differences between ankylosing spondylitis (AS) and axial psoriatic arthritis …

The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of
genes in the major histocompatibility complex whose name goes back to its discovery in …

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial
roles in host defence against microbial organisms and the development of inflammatory …

Purpose Approximately 30% of patients with psoriasis will develop psoriatic arthritis (PsA),
leading to a decreased quality of life for the patient caused by increasing disability and …

Axial spondyloarthritis (axial-SpA) is a multifactorial disease characterized by inflammation
in sacroiliac joints and spine, bone reabsorption, and aberrant bone deposition, which may …

Background Despite clear evidence of nonlinear interactions in the molecular architecture of
polygenic diseases, linear models have so far appeared optimal in genotype-to-phenotype …

The 'MHC-I (major histocompatibility complex class I)-opathy'concept describes a family of
inflammatory conditions with overlapping clinical manifestations and a strong genetic link to …

Purpose This review aims at investigating pathophysiological mechanisms in
spondyloarthritis (SpA). Analysis of genetic factors, immunological pathways, and …