Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral …

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …

Prior to the development of genome‐wide arrays and whole genome sequencing
technologies, heritability estimation mainly relied on the study of related individuals. Over …

Identification of gene-by-environment interactions (GxE) is crucial to understand the
interplay of environmental effects on complex traits. However, current methods evaluating …

Background Coronary heart disease (CHD) is the leading cause of death in the world.
Unfortunately, many of the key diagnostic tools for CHD are insensitive, invasive, and costly; …

The heritability explained by local ancestry markers in an admixed population (h γ 2)
provides crucial insight into the genetic architecture of a complex disease or trait. Estimation …

Despite extensive research on global heritability estimation for complex traits, few methods
accurately dissect local heritability. A precise local heritability estimate is crucial for high …

Existing SNP-heritability estimators that leverage summary statistics from genome-wide
association studies (GWAS) are much less efficient (ie, have larger standard errors) than the …

Genome-wide association studies seek to attribute disease risk to DNA regions and facilitate
subject-specific prediction and patient stratification. For later-life diseases, inference from …

When ordinary people talk to geneticists, the questions they often most want to have
answered are:“How much does genetics matter for behavior?” and “Is race real?”. These will …