Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management

JS Knight, DW Branch, TL Ortel - bmj, 2023 - bmj.com
Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease propelled by
circulating autoantibodies that recognize cell surface phospholipids and phospholipid …

Systemic lupus erythematosus and cardiovascular disease

J Frostegård - Journal of Internal Medicine, 2023 - Wiley Online Library
The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

Biological therapy in systemic lupus erythematosus, antiphospholipid syndrome, and Sjögren's syndrome: evidence-and practice-based guidance

A Marinho, J Delgado Alves, J Fortuna, R Faria… - Frontiers in …, 2023 - frontiersin.org
Systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and Sjögren's
syndrome (SS) are heterogeneous autoimmune diseases. Severe manifestations and …

Systematic literature review and meta-analysis of venous thromboembolism events in systemic lupus erythematosus

N Bello, KJ Meyers, J Workman… - Rheumatology and …, 2023 - Springer
The objective of this work was to conduct a systematic literature review (SLR) and meta-
analysis (MA) to evaluate the relative risk (RR) of venous thromboembolism (VTE) events …

Whole blood transcriptome identifies interferon-regulated genes as key drivers in thrombotic primary antiphospholipid syndrome

KM Verrou, PP Sfikakis, MG Tektonidou - Journal of Autoimmunity, 2023 - Elsevier
Objective Pathogenesis of antiphospholipid syndrome (APS) isn't fully elucidated. We aimed
to identify gene signatures characterizing thrombotic primary APS (thrPAPS) and subgroups …

Metabolic syndrome in antiphospholipid syndrome versus rheumatoid arthritis and diabetes mellitus: association with arterial thrombosis, cardiovascular risk …

E Bolla, N Tentolouris, PP Sfikakis… - Frontiers in …, 2023 - frontiersin.org
Background Cardiovascular disease (CVD) is the foremost cause of morbidity and deaths in
antiphospholipid syndrome (APS), driven by thrombo-inflammation and atherothrombosis …

B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

X Du, X Ma, Y Tan, F Shao, C Li, Y Zhao… - … and Targeted Therapy, 2023 - nature.com
Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that
affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies …

Antiphospholipid syndrome in pregnancy: new and old pathogenetic mechanisms

S D'Ippolito, G Barbaro, C Paciullo, C Tersigni… - International journal of …, 2023 - mdpi.com
The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized,
according to the Sydney criteria, by the persistent presence of autoantibodies directed …

Prevalence of antiphospholipid antibodies and association with incident cardiovascular events

Y Zuo, S Navaz, W Liang, C Li, CR Ayers… - JAMA Network …, 2023 - jamanetwork.com
Importance The prevalence of antiphospholipid antibodies (aPL) and their association with
future atherosclerotic cardiovascular disease (ASCVD) risk has yet to be thoroughly …

Survey on antiphospholipid syndrome diagnosis and antithrombotic treatment in patients with ischemic stroke, other brain ischemic injury, or arterial thromboembolism …

H Cohen, DJ Werring, A Chandratheva, P Mittal… - Journal of Thrombosis …, 2023 - Elsevier
Background The optimal strategy for diagnosis and antithrombotic treatment of patients with
antiphospholipid syndrome (APS)–associated acute ischemic stroke (AIS), transient …