Making a good egg: human oocyte health, aging, and in vitro development

EE Telfer, J Grosbois, YL Odey… - Physiological …, 2023 - journals.physiology.org
Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

[HTML][HTML] Mechanisms of ovarian aging in women: a review

X Wang, L Wang, W Xiang - Journal of Ovarian Research, 2023 - Springer
Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

[HTML][HTML] Landscape of pathogenic mutations in premature ovarian insufficiency

H Ke, S Tang, T Guo, D Hou, X Jiao, S Li, W Luo… - Nature Medicine, 2023 - nature.com
Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency

S Shekari, S Stankovic, EJ Gardner, G Hawkes… - Nature Medicine, 2023 - nature.com
Premature ovarian insufficiency (POI) affects 1% of women and is a leading cause of
infertility. It is often considered to be a monogenic disorder, with pathogenic variants in~ 100 …

Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study

Z Wei, B Yang, T Tang, Z Xiao, F Ye, X Li… - Cancer …, 2023 - Wiley Online Library
Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …

[HTML][HTML] An atlas of genetic determinants of forearm fracture

M Nethander, S Movérare-Skrtic, A Kämpe, E Coward… - Nature Genetics, 2023 - nature.com
Osteoporotic fracture is among the most common and costly of diseases. While reasonably
heritable, its genetic determinants have remained elusive. Forearm fractures are the most …

Women's reproductive milestones and cardiovascular disease risk: a review of reports and opportunities from the CARDIA study

C Kim, J Catov, PJ Schreiner, D Appiah… - Journal of the …, 2023 - Am Heart Assoc
In 1985 to 1986, the CARDIA (Coronary Artery Risk Development in Young Adults) study
enrolled 5115 Black or White participants, including 2788 women, aged 18 to 30 years. Over …

[HTML][HTML] Review of mendelian randomization studies on age at natural menopause

X Zhang, Z Huangfu, S Wang - Frontiers in Endocrinology, 2023 - frontiersin.org
Menopause marks the end of the reproductive phase of life. Based on epidemiological
studies, abnormal age at natural menopause (ANM) is thought to contribute to a number of …

[HTML][HTML] Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome

S Risal, C Li, Q Luo, R Fornes, H Lu, G Eriksson… - Cell Reports …, 2023 - cell.com
The transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female
progeny are being revealed. As there is evidence that a male equivalent of PCOS may …

[HTML][HTML] Генетические детерминанты уровня половых гормонов у больных эндометриозом

ИО Головченко - Научные результаты биомедицинских …, 2023 - cyberleninka.ru
Актуальность: Эндометриоз-это хроническое гормонозависимое воспалительное
заболевание, определяемое наличием очагов эндометриальной ткани вне полости …