Distinct Inhibition Modes of New Delhi Metallo-β-lactamase-1 Revealed by NMR Spectroscopy
K Cheng, Q Wu, C Yao, Z Chai, L Jiang, M Liu, C Li - JACS Au, 2023 - ACS Publications
The wide spread of antibiotic-resistant “superbugs” containing New Delhi metallo-β-
lactamase-1 (NDM-1) has become a threat to human health. However, clinically valid …
lactamase-1 (NDM-1) has become a threat to human health. However, clinically valid …
Visible light-induced synthesis of polysubstituted oxazoles from diazo compounds
J Bai, D Qi, Z Song, B Li, L Guo, C Yang… - Organic & Biomolecular …, 2023 - pubs.rsc.org
Herein, a visible light-induced synthesis of polysubstituted oxazoles from diazo compounds
is reported. This developed synthetic method differs from traditional routes that rely on …
is reported. This developed synthetic method differs from traditional routes that rely on …
Identification of novel metallo-β-lactamases inhibitors using ligand-based pharmacophore modelling and structure-based virtual screening
Abstract Metallo-β-lactamases (MBLs) are a group of enzymes that hydrolyze the most
commonly used β-lactam-based antibiotics, leading to the development of multi-drug …
commonly used β-lactam-based antibiotics, leading to the development of multi-drug …
Prediction of Phytochemicals for Their Potential to Inhibit New Delhi Metallo β-Lactamase (NDM-1)
The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been
impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …
impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …
Sustainable Synthesis of Azo-Linked 4-Arylidene-2-Aryloxazolones Using Fe3O4@SiPr@vanillin@TGA Nanocomposite
Abstract Bis (thioglycolic acid)-vanillin (2, 2′-(((4-hydroxy-3-methoxyphenyl) methylene) bis
(sulfanediyl)) diacetic acid)‐functionalized silica‐coated Fe3O4 magnetic nanocomposite …
(sulfanediyl)) diacetic acid)‐functionalized silica‐coated Fe3O4 magnetic nanocomposite …
Fe3O4@SP@Chitosan@Fe3O4 Nanocomposite: A Catalyst with Double Magnetite Parts for Sustainable Synthesis of Novel Azo-Linked 4-Benzylidene-2 …
Chitosan‐functionalized silica‐double magnetite parts that contains magnetite in the core
and outer layer of synthetic nanoparticles (Fe3O4@ SP@ chitosan@ Fe3O4) were prepared …
and outer layer of synthetic nanoparticles (Fe3O4@ SP@ chitosan@ Fe3O4) were prepared …
Synthesis, crystal structure, and Hirschfeld surface analysis of novel ethyl 5-bromo-2-(4-methoxyphenyl) oxazole-4-carboxylate
A new oxazole derivative, ethyl 5-bromo-2-(4-methoxyphenyl) oxazole-4-carboxylate, was
synthesized and characterized by IR spectroscopy, 13 C NMR, Mass spectroscopy, and …
synthesized and characterized by IR spectroscopy, 13 C NMR, Mass spectroscopy, and …
Targeting Bacterial Resistance: Rational Design and Evaluation of Antibiotic Combinations with Adjuvants
Y Yuliandra - 2023 - ses.library.usyd.edu.au
Antimicrobial resistance (AMR) has become a major global health concern, posing
significant challenges to modern medicine. The diminishing pipeline of novel antimicrobial …
significant challenges to modern medicine. The diminishing pipeline of novel antimicrobial …
Fluorinated Captopril Analogues as Inhibitors of the Metallo-Β-Lactamase NDM-1
A Kondratieva, K Palica, C Frøhlich, HKS Leiros… - Available at SSRN … - papers.ssrn.com
Bacterial resistance to the majority of clinically used β-lactam antibiotics is a global health
threat and, consequently, the driving force for the development of new inhibitors. In this …
threat and, consequently, the driving force for the development of new inhibitors. In this …