Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Irritable bowel syndrome (IBS) affects 5–10% of the global population. Up to one-third of
people with IBS also experience anxiety or depression. Gastrointestinal and psychological …

Importance Physical health and chronic medical comorbidities are underestimated,
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …

Globally, too many people die prematurely from suicide and the physical comorbidities
associated with mental illness and mental distress. The purpose of this Review is to mobilise …

Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Objectives The primary objectives of these international guidelines were to provide a global
audience of clinicians with (a) a series of evidence-based recommendations for the …

Background Cardiovascular disease is a major cause of excess mortality in people with
schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of …

Background Mental disorders are associated with premature mortality. There is increasing
research examining life expectancy and years-of-potential-life-lost (YPLL) to quantify the …