Together, loss-and gain-of-function experiments have identified the bone-derived secreted
molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following …

Muscles and bones are intricately connected tissues displaying marked co-variation during
development, growth, aging, and in many diseases. While the diagnosis and treatment of …

Increasing evidence indicates that exercise has beneficial effects on chronic inflammation,
cardiorespiratory function, muscle and bone strength and metabolic markers in adults with …

Estrogens (estradiol, estriol, and estrone) are important hormones that directly and indirectly
regulate the metabolism and function of bone and skeletal muscle via estrogen receptors …

The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …

Osteocalcin was reported to regulate muscle energy metabolism, thus fighting fatigue during
exercise. The current work aimed to investigate the anti-fatigue effect and the underlying …

Regular exercise leads to widespread salutary effects, and there is increasing recognition
that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited …

The beneficial effects of exercise on the proper functioning of the body have been firmly
established. Multi-systemic metabolic regulation of exercise is the consequence of …

Maintenance of skeletal health is tightly regulated by osteocytes, osteoblasts, and
osteoclasts via coordinated secretion of bone-derived factors, termed osteokines. Disruption …

Despite the importance of vitamin K to maintaining normal growth, survival, and bone health
in fish, studies on the effect of different dietary levels of vitamin K on marine fish larvae are …