Microtubules, formed by α-and β-tubulin heterodimer, are considered as a major target to
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …

An efficient and practical approach for the synthesis of tetrasubstituted pyridines has been
described via the Imidazole hydrochloride-promoted reaction of enaminones with DMSO …

Extensive preclinical studies have shown that colchicine-binding site inhibitors (CBSIs) are
promising drug candidates for cancer therapy. Although numerous CBSIs were generated …

Polymerization of tubulin dimers to form microtubules is one of the key events in cell
proliferation. The inhibition of this event has long been recognized as a potential treatment …

In previous studies, we synthesized different imidazo− pyrazoles 1 and 2 with interesting
anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure …

Carbendazim derivatives, commonly used as antiparasitic drugs, have shown potential as
anticancer agents due to their ability to induce cell cycle arrest and apoptosis in human …

The colchicine binding site of tubulin is a promising target for discovering novel antitumour
agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate …

The activity of four typical organotin benzohydroxamate compounds (OTBH) with the
different electronegativity of fluorine and chlorine atoms was assessed both in vitro and in …

An arsenal of molecular tools with increasingly diversified mechanisms of action is being
developed by the scientific community to enable biological interrogation and pharmaceutical …

HIV-1 Rev is an essential regulatory protein that transports unspliced and partially spliced
viral mRNAs from the nucleus to the cytoplasm for the expression of viral structural proteins …