Using autopsies to dissect COVID-19 pathogenesis

F Heinrich, KD Mertz, M Glatzel, M Beer… - Nature …, 2023 - nature.com
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19.
Suitable models were missing at the beginning of the pandemic, and studies investigating …

SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …

Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms

AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
Numerous investigations have demonstrated significant and long-lasting neurological
manifestations of COVID-19. It has been suggested that as many as four out of five patients …

Biological age is increased by stress and restored upon recovery

JR Poganik, B Zhang, GS Baht, A Tyshkovskiy, A Deik… - Cell Metabolism, 2023 - cell.com
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Effect of peripheral cellular senescence on brain aging and cognitive decline

V Budamagunta, A Kumar, A Rani, L Bean… - Aging …, 2023 - Wiley Online Library
We examine similar and differential effects of two senolytic treatments, ABT‐263 and
dasatinib+ quercetin (D+ Q), in preserving cognition, markers of peripheral senescence, and …

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

F Sauve, S Nampoothiri, SA Clarke, D Fernandois… - …, 2023 - thelancet.com
Background We have recently demonstrated a causal link between loss of gonadotropin-
releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive …

Spike Protein Fragments Promote Alzheimer's Amyloidogenesis

S Cao, Z Song, J Rong, N Andrikopoulos… - … Applied Materials & …, 2023 - ACS Publications
Alzheimer's disease (AD) is a major cause of dementia inducing memory loss, cognitive
decline, and mortality among the aging population. While the amyloid aggregation of …

Gut-brain pathogenesis of post-acute COVID-19 neurocognitive symptoms

AM Plummer, YL Matos, HC Lin, SG Ryman… - Frontiers in …, 2023 - frontiersin.org
Approximately one third of non-hospitalized coronavirus disease of 2019 (COVID-19)
patients report chronic symptoms after recovering from the acute stage of severe acute …

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

K Wang, M Khoramjoo, K Srinivasan, PMK Gordon… - Cell Reports …, 2023 - cell.com
The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often
associated with debilitating symptoms and adverse multisystem consequences. We obtain …

Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP: TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of …

MG Frank, M Fleshner, SF Maier - Brain, Behavior, and Immunity, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …