The effect of aldosterone on cardiorenal and metabolic systems

H Otsuka, M Abe, H Kobayashi - International Journal of Molecular …, 2023 - mdpi.com
Aldosterone, a vital hormone of the human body, has various pathophysiological roles. The
excess of aldosterone, also known as primary aldosteronism, is the most common …

Primary aldosteronism: molecular medicine meets public health

EAB Azizan, WM Drake, MJ Brown - Nature Reviews Nephrology, 2023 - nature.com
Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial

X Wu, R Senanayake, E Goodchild, WA Bashari… - Nature Medicine, 2023 - nature.com
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …

Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism

J Rege, S Bandulik, K Nanba, C Kosmann… - Nature Genetics, 2023 - nature.com
Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Accuracy of Gallium-68 Pentixafor Positron Emission Tomography–Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism

J Hu, T Xu, H Shen, Y Song, J Yang, A Zhang… - JAMA Network …, 2023 - jamanetwork.com
Importance Adrenal vein sampling (AVS) is the recommended procedure for subtyping
primary aldosteronism (PA) as unilateral PA (UPA) or bilateral PA (BPA), with different …

Underdiagnosis of primary aldosteronism: a review of screening and detection

MF Hernandez, V Bhalla - American Journal of Kidney Diseases, 2023 - Elsevier
A clinical condition may be missed due to its higher-than-recognized prevalence or
inadequate diagnostic screening. Primary aldosteronism suffers from both of these factors …

Importance of dietary salt restriction for patients with primary aldosteronism during treatment with mineralocorticoid receptor antagonists: the potential importance of …

Y Yoshida, R Fujiki, M Kinoshita, K Sada… - Hypertension …, 2023 - nature.com
We measured dietary salt intake in 26 patients with primary aldosteronism treated with
mineralocorticoid receptor antagonists and evaluated whether plasma renin levels were …

Functional nodules in primary aldosteronism: identification of CXCR4 expression with 68Ga-pentixafor PET/CT

Y Gao, J Ding, Y Cui, T Li, H Sun, D Zhao, Y Zhang… - European …, 2023 - Springer
Objectives We analyzed the diagnostic efficiency of 68Ga-pentixafor PET/CT for functional
nodules in primary aldosteronism (PA). Furthermore, we compared the correlation of CXCR4 …

Histopathologic features of adrenal cortical carcinoma

A Gambella, M Volante, M Papotti - Advances in Anatomic …, 2023 - journals.lww.com
Adrenal cortical carcinoma (ACC) is a rare and aggressive malignancy that poses
challenging issues regarding the diagnostic workup. Indeed, no presurgical technique or …

Primary aldosteronism in pregnancy

V Forestiero, E Sconfienza, P Mulatero… - Reviews in Endocrine …, 2023 - Springer
Primary aldosteronism (PA) is the most common form of secondary hypertension. Although
hypertensive disorders seem to affect around 5–10% of pregnancies worldwide, literature …