Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

The blood-brain barrier (BBB) is located at the interface between the vascular system and
the brain parenchyma, and is responsible for communication with systemic circulation and …

The adjustment of cellular redox homeostasis is essential in when responding to
environmental perturbations, and the mechanism by which cells distinguish between normal …

During embryonic development, cardiomyocytes undergo differentiation and maturation,
processes that are tightly regulated by tissue-specific signaling cascades. Although redox …

Xanthones are natural secondary metabolites that possess great potential as
neuroprotective agents due to their prominent biological effects on Alzheimer's disease …

Evidence demonstrated that metabolic-associated T cell abnormalities could be detected in
the early stage of RA development. In this context, molecular evaluations have revealed …

Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative
disease. There is no cure currently. The discovery that mutations in the gene SOD1 are a …

Cysteine sulfonic acid, a product of protein oxidative damage, is an important sign by which
the body and cells sense oxidative stress. Cigarette smoke (CS) can trigger inflammatory …

The retina is one of the highest oxygen-consuming tissues because visual transduction and
light signaling processes require large amounts of ATP. Thus, because of the high energy …

Mutations of Ras proteins are believed to be among the most prominent causes of cancer.
There is increasing evidence that the activity of Ras may be controlled by the redox state of …