Endothelial dysfunction in neurodegenerative diseases

YC Fang, YC Hsieh, CJ Hu, YK Tu - International journal of molecular …, 2023 - mdpi.com
The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

[HTML][HTML] Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential

Y Chen, Y He, J Han, W Wei, F Chen - Frontiers in Aging …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
accumulation of amyloid-beta (Aβ), hyperphosphorylation of tau, and neuroinflammation in …

The presence and severity of NAFLD are associated with cognitive impairment and hippocampal damage

Y Miao, B Zhang, X Sun, X Ma, D Fang… - The Journal of …, 2023 - academic.oup.com
Context Although cognitive impairment in nonalcoholic fatty liver disease (NAFLD) has
received attention in recent years, little is known about detailed cognitive functions in …

[HTML][HTML] Systemic inflammation causes microglial dysfunction with a vascular AD phenotype

P Bathini, I Dupanloup, E Zenaro, E Terrabuio… - Brain, Behavior, & …, 2023 - Elsevier
Background Studies in rodents and humans have indicated that inflammation outside CNS
(systemic inflammation) affects brain homeostasis contributing to neurodevelopmental …

Involvement of an aberrant vascular system in neurodevelopmental, neuropsychiatric, and neuro-degenerative diseases

K Ishihara, K Takata, K Mizutani - Life, 2023 - mdpi.com
The vascular system of the prenatal brain is crucial for the development of the central
nervous system. Communication between vessels and neural cells is bidirectional, and …

The heritability of cerebral amyloid in older people and its relationship to vascular risk factors, cerebral small vessel disease and cognition

R Koncz - 2023 - unsworks.unsw.edu.au
Abnormal β-amyloid (Aβ) plaque accumulation, a hallmark pathological feature of
Alzheimer's disease (AD), commonly co-occurs with cerebral small vessel disease (SVD) …