[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies
COVID-19 pandemic is a global public health emergency. Despite extensive research, there
are still few effective treatment options available today. Neutralizing-antibody-based …
are still few effective treatment options available today. Neutralizing-antibody-based …
[HTML][HTML] Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants
SARS-CoV-2 Omicron variants feature highly mutated spike proteins with extraordinary
abilities in evading antibodies isolated earlier in the pandemic. Investigation of memory B …
abilities in evading antibodies isolated earlier in the pandemic. Investigation of memory B …
[HTML][HTML] Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection
Y Guo, G Zhang, Q Yang, X Xie, Y Lu, X Cheng… - Nature …, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant evades most currently approved neutralizing
antibodies (nAbs) and caused drastic decrease of plasma neutralizing activity elicited by …
antibodies (nAbs) and caused drastic decrease of plasma neutralizing activity elicited by …
Major royal jelly proteins elicited suppression of SARS-CoV-2 entry and replication with halting lung injury
MM Abu-Serie, NH Habashy - International Journal of Biological …, 2023 - Elsevier
For reasons of high transmissibility and virulence, Alpha (UK, B. 1.1. 7) and Beta (South
African, B. 1.351) SARS-CoV-2 variants are classified with other types as variants of …
African, B. 1.351) SARS-CoV-2 variants are classified with other types as variants of …
[HTML][HTML] Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-
CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral …
CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral …
SARS‐CoV‐2 neutralising antibody therapies: Recent advances and future challenges
The COVID‐19 pandemic represents an unparalleled global public health crisis. Despite
concerted research endeavours, the repertoire of effective treatment options remains limited …
concerted research endeavours, the repertoire of effective treatment options remains limited …
Prediction of antibody binding to SARS-CoV-2 RBDs
E Wang - Bioinformatics Advances, 2023 - academic.oup.com
The ability to predict antibody–antigen binding is essential for computational models of
antibody affinity maturation and protein design. While most models aim to predict binding for …
antibody affinity maturation and protein design. While most models aim to predict binding for …
SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage
The recent emergence of the omicron variant of the SARS-CoV-2 virus with large numbers of
mutations has raised concern about a potential new surge in infections. Here we use …
mutations has raised concern about a potential new surge in infections. Here we use …
Novel B-Cell Epitopes of Non-Neutralizing Antibodies in the Receptor-Binding Domain of the SARS-CoV-2 S-Protein with Different Effects on the Severity of COVID-19
AL Matveev, OV Pyankov, YA Khlusevich… - Biochemistry …, 2023 - Springer
Antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein (RBD S-
protein) contribute significantly to the humoral immune response during coronavirus …
protein) contribute significantly to the humoral immune response during coronavirus …