Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
Applications of deep learning in understanding gene regulation
Gene regulation is a central topic in cell biology. Advances in omics technologies and the
accumulation of omics data have provided better opportunities for gene regulation studies …
accumulation of omics data have provided better opportunities for gene regulation studies …
RCSB Protein Data Bank (RCSB. org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from …
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …
Global detection of human variants and isoforms by deep proteome sequencing
An average shotgun proteomics experiment detects approximately 10,000 human proteins
from a single sample. However, individual proteins are typically identified by peptide …
from a single sample. However, individual proteins are typically identified by peptide …
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
J Humphrey, S Venkatesh, R Hasan, JT Herb… - Nature …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neurodegenerative disease
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
N Bancaro, B Calì, M Troiani, AR Elia, RA Arzola… - Cancer cell, 2023 - cell.com
Tumor cells promote the recruitment of immunosuppressive neutrophils, a subset of myeloid
cells driving immune suppression, tumor proliferation, and treatment resistance …
cells driving immune suppression, tumor proliferation, and treatment resistance …
GENCODE: reference annotation for the human and mouse genomes in 2023
GENCODE produces high quality gene and transcript annotation for the human and mouse
genomes. All GENCODE annotation is supported by experimental data and serves as a …
genomes. All GENCODE annotation is supported by experimental data and serves as a …
FAVOR: functional annotation of variants online resource and annotator for variation across the human genome
Large biobank-scale whole genome sequencing (WGS) studies are rapidly identifying a
multitude of coding and non-coding variants. They provide an unprecedented resource for …
multitude of coding and non-coding variants. They provide an unprecedented resource for …
LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations
Z Li, L Liu, C Feng, Y Qin, J Xiao… - Nucleic Acids …, 2023 - academic.oup.com
LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been
used in a wide range of lncRNA studies across various biological contexts. Here, we present …
used in a wide range of lncRNA studies across various biological contexts. Here, we present …
IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
Y Pan, JW Phillips, BD Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely
unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from …
unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from …