[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] Broadly neutralizing antibodies against COVID-19

D Zhou, J Ren, EE Fry, DI Stuart - Current Opinion in Virology, 2023 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of
infections and millions of deaths, however, human monoclonal antibodies (mAbs) can be an …

Antigenicity and infectivity characterisation of SARS-CoV-2 BA. 2.86

S Yang, Y Yu, F Jian, W Song, A Yisimayi… - The Lancet Infectious …, 2023 - thelancet.com
The newly emerged SARS-CoV-2 saltation variant, BA. 2.86, has raised global concern
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …

[HTML][HTML] Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …

Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)

CW Cheng, CY Wu, SW Wang… - Proceedings of the …, 2023 - National Acad Sciences
Since the outbreak of Severe Acute Respiratory Syndrome Virus-2 (SARS-CoV-2) in 2019,
more than 15 million spike protein sequences have been identified, raising a new challenge …

[HTML][HTML] Immunogenicity and efficacy of a novel multi-patch SARS-CoV-2/COVID-19 vaccine candidate

B Perdiguero, L Marcos-Villar, M López-Bravo… - Frontiers in …, 2023 - frontiersin.org
Introduction While there has been considerable progress in the development of vaccines
against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has …

[HTML][HTML] A Candidate DNA Vaccine Encoding the Native SARS-CoV-2 Spike Protein Induces Anti-Subdomain 1 Antibodies

A Frische, V Gunalan, KA Krogfelt, A Fomsgaard… - Vaccines, 2023 - mdpi.com
The ideal vaccine against viral infections should elicit antibody responses that protect
against divergent strains. Designing broadly protective vaccines against SARS-CoV-2 and …

[HTML][HTML] Longitudinal Variations in Antibody Responses against SARS-CoV-2 Spike Epitopes upon Serial Vaccinations

D Yalcin, SJ Bennett, J Sheehan, AJ Trauth… - International journal of …, 2023 - mdpi.com
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) impacted healthcare, the workforce, and worldwide socioeconomics. Multi …

[HTML][HTML] Structural understanding of SARS-CoV-2 virus entry to host cells

K Le, S Kannappan, T Kim, JH Lee… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with …

[HTML][HTML] The Effect of Select SARS-CoV-2 N-Linked Glycan and Variant of Concern Spike Protein Mutations on C-Type Lectin-Receptor-Mediated Infection

A Bains, W Guan, PJ LiWang - Viruses, 2023 - mdpi.com
The SARS-CoV-2 virion has shown remarkable resilience, capable of mutating to escape
immune detection and re-establishing infectious capabilities despite new vaccine rollouts …