Depression and anxiety are the most common mental illnesses affecting children and
adolescents, significantly harming their well-being. Research has shown that regular …

Lifelong indices of maladaptive behavior or illness often stem from early physiological
aberrations during periods of dynamic development. This is especially true when …

Early-life adversity affects long-term health outcomes but there is considerable
interindividual variability in susceptibility to environmental influences. We proposed that …

Emotional stress is a leading risk factor in the development of neuropsychiatric disorders
possibly via immune activation. P2X7 receptors promote neuroinflammation, and research …

Elevated inflammatory activity is one possible pathway through which exposure to childhood
adversity engenders risk for physical and psychiatric illnesses. Limited research has …

Stress exposure during early stages of life elevates the risk of developing
psychopathologies and psychiatric illness in later life. The brain and immune system are not …

Inflammation has an important predictive role for long-term health. This is also true when
looking at the specific population of trauma survivors with PTSD. There are emerging …

Early adverse experience is related to psychiatric illness that occurs decades later. The
mechanisms underlying this phenomenon have not been fully identified. There is a …

Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are
felt, as well as when and how these emotions are experienced or expressed. It is a focal …

Acute major depression is characterized by specific abnormalities in the way emotional
material is attended to. In late stages of stimulus processing, clinically depressed and …