Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Biological milieus are highly crowded and heterogeneous systems where organization of
macromolecules within nanodomains (eg membraneless compartments) is vital to the …

Cellular homeostasis requires the robust control of biomolecule concentrations, but how do
millions of mRNAs coordinate their stoichiometries in the face of dynamic translational …

During folliculogenesis, the oocyte and surrounding cumulus cells form an ensemble called
the cumulus-oocyte complex (COC). Due to their interdependence, research on the COC …

In human female primordial germ cells, the transition from mitosis to meiosis begins from the
fetal stage. In germ cells, meiosis is arrested at the diplotene stage of prophase in meiosis I …

The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

Fully grown oocytes remain transcriptionally quiescent, yet many maternal mRNAs are
synthesized and retained in growing oocytes. We now know that maternal mRNAs are …

Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …

Mammalian oogenesis features reliance on the mRNAs produced and stored during early
growth phase. These are essential for producing an oocyte competent to undergo meiotic …

The biology of preimplantation embryo gene expression began 56 years ago with studies of
the effects of protein synthesis inhibition and discovery of changes in embryo metabolism …