Clustered regularly interspersed short pallindromic repeats (CRISPR) and CRISPR
associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence …

We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …

Hydrogels are attractive materials for tissue engineering, but efforts to date have shown
limited ability to produce the microstructural features necessary to promote cellular self …

Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …

Drug‐induced cardiotoxicity is regarded as a major hurdle in the early stages of drug
development. Although there are various methods for preclinical cardiotoxicity tests, they …

One of the leading challenges facing the pharmaceutical industry today is the 'high attrition
rate problem', with a large number of drug candidates being abandoned before reaching the …

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-
threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 …

Cardiomyocytes are responsible for generating contractile force to pump blood throughout
the body and are very sensitive to mechanical forces and can initiate mechano-electric …

Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS)
is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase …

We developed a heart-on-a-chip platform that integrates highly flexible, vertical, 3D
micropillar electrodes for electrophysiological recording and elastic microwires for the …