Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The use of neuroimaging techniques in the early and differential diagnosis of dementia

L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Isosorbide mononitrate and cilostazol treatment in patients with symptomatic cerebral small vessel disease: the lacunar intervention trial-2 (LACI-2) randomized …

JM Wardlaw, LJ Woodhouse, II Mhlanga… - JAMA …, 2023 - jamanetwork.com
Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar
stroke), is the most common cause of vascular cognitive impairment, and impairs mobility …

Iatrogenic cerebral amyloid angiopathy post neurosurgery: frequency, clinical profile, radiological features, and outcome

K Kaushik, ES Van Etten, B Siegerink, LJ Kappelle… - Stroke, 2023 - Am Heart Assoc
Background: Prion-like transmission of amyloid-ß through cadaveric dura, decades after
neurosurgical procedures, has been hypothesized as an iatrogenic cause of cerebral …

[HTML][HTML] Cerebral small vessel disease–related dementia: more questions than answers

FM Elahi, MM Wang, JF Meschia - Stroke, 2023 - journals.lww.com
Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …

[HTML][HTML] Applications of generative adversarial networks in neuroimaging and clinical neuroscience

R Wang, V Bashyam, Z Yang, F Yu, V Tassopoulou… - Neuroimage, 2023 - Elsevier
Generative adversarial networks (GANs) are one powerful type of deep learning models that
have been successfully utilized in numerous fields. They belong to the broader family of …

Disentangling the effects of Alzheimer's and small vessel disease on white matter fibre tracts

A Dewenter, MA Jacob, M Cai, B Gesierich, P Hager… - Brain, 2023 - academic.oup.com
Alzheimer's disease and cerebral small vessel disease are the two leading causes of
cognitive decline and dementia and coexist in most memory clinic patients. White matter …

Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases

S Lista, A Vergallo, SJ Teipel, P Lemercier… - Ageing research …, 2023 - Elsevier
Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …

Spatial patterns of white matter hyperintensities: a systematic review

J Botz, V Lohner, MD Schirmer - Frontiers in aging neuroscience, 2023 - frontiersin.org
Background White matter hyperintensities are an important marker of cerebral small vessel
disease. This disease burden is commonly described as hyperintense areas in the cerebral …

Cerebrovascular reactivity in patients with small vessel disease: a cross-sectional study

E Sleight, MS Stringer, U Clancy, C Arteaga… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: Cerebrovascular reactivity (CVR) is inversely related to white matter
hyperintensity severity, a marker of cerebral small vessel disease (SVD). Less is known …