The N-degron pathway is a degradative system in which the N-terminal residues of proteins
modulate the half-lives of proteins and other cellular materials. The majority of amino acids …

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

In response to lysosomal damage, cells engage several quality-control mechanisms,
including the selective isolation and degradation of damaged lysosomes by lysophagy …

Acute kidney injury (AKI) can lead to loss of kidney function and a substantial increase in
mortality. The burst of reactive oxygen species (ROS) plays a key role in the pathological …

Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal
neuron degeneration in Parkinson's disease (PD). Several studies in experimental models …

Summary p62 is a well-characterized autophagy receptor that recognizes and sequesters
specific cargoes into autophagosomes for degradation. p62 promotes the assembly and …

Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate
substrates for lysosomal degradation during autophagy. Phase separated p62 body plays …

Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic
substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are …

NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in
innate immune signaling, cell death regulation and host-pathogen interactions. Here we …