Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological
disease holds great promise; however, there is a lack of well-curated lines from a large array …

Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from
many diverse genetic causes. Although therapeutics specifically targeting known causal …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss, with additional pathophysiological involvement of non …

Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a
primary example of cell-type specificity in neurodegenerative diseases. Using isogenic pairs …