The effects and pathogenesis of PM2. 5 and its components on chronic obstructive pulmonary disease

Q Wang, S Liu - … Journal of Chronic Obstructive Pulmonary Disease, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD), a heterogeneous disease, is the leading
cause of death worldwide. In recent years, air pollution, especially particulate matter (PM) …

Identification of genetic biomarkers, drug targets and agents for respiratory diseases utilising integrated bioinformatics approaches

FF Ahmed, AD Das, MJ Sumi, MZ Islam, MS Rahman… - Scientific Reports, 2023 - nature.com
Respiratory diseases (RD) are significant public health burdens and malignant diseases
worldwide. However, the RD-related biological information and interconnection still need to …

Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress

W Tu, X Xiao, J Lu, X Liu, E Wang, R Yuan… - Frontiers in …, 2023 - frontiersin.org
Background Metal components of environmental PM2. 5 are associated with the
exacerbation of allergic diseases like asthma. In our recent hospital-based population study …

Wogonin alleviates BaP‐induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression

Z Ni, H Ma, X Li, L Zou, Z Liu, X Wang… - Environmental …, 2023 - Wiley Online Library
Abstract Benzo [a] pyrene (BaP) is a common air pollutant that has been reported to cause
oxidative stress and carcinogenesis. Wogonin, a flavonoid compound extracted from the …

Evaluation of the impact of BaP exposure on the gut microbiota and allergic responses in an OVA-sensitized mouse model

B Du, X Xiao, H Wang, W Li, Z Xia… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Exposure to environmental pollutants, including benzo [a] pyrene (BaP), has
been implicated in allergic diseases and intestinal microbiota homeostasis, but the …

Fine particulate matter (PM2. 5) induces inhibitory memory alveolar macrophages through the AhR/IL-33 pathway

Y Liu, Q Yuan, X Zhang, Z Chen, X Jia, M Wang, T Xu… - Cellular …, 2023 - Elsevier
Abstract Fine particulate matter (PM2. 5) concentrations have decreased in the past decade.
The adverse effects of acute PM2. 5 exposure on respiratory diseases have been well …

Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo [a] …

M Imran, F Chalmel, O Sergent, B Evrard… - Cell Biology and …, 2023 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic for which environmental
contaminants are increasingly recognized as important etiological factors. Among them, the …

Inhibition of RNF182 mediated by Bap promotes non-small cell lung cancer progression

Y Liu, L Ouyang, C Mao, Y Chen, N Liu, L Chen… - Frontiers in …, 2023 - frontiersin.org
Introduction Ubiquitylation that mediated by ubiquitin ligases plays multiple roles not only in
proteasome-mediated protein degradation but also in various cellular process including …

Mechanisms of Formation and Persistence of IgE Products and Potential Innovative Means of Therapy for Allergic Pathologies

DB Chudakov, MV Konovalova, MA Streltsova… - Applied Biochemistry …, 2023 - Springer
This review is devoted to the analysis of the main mechanisms of the formation of IgE-
producing cells in the body and a brief review of the main, most striking candidate agents for …

Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks …

JR Schmidt, J Haupt, S Riemschneider… - Frontiers in …, 2023 - frontiersin.org
Introduction The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor
that regulates a broad range of target genes involved in the xenobiotic response, cell cycle …