Abstract α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of
mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

Receptor tyrosine kinase (RTK), c-Met, is overexpressed and hyper active in renal cell
carcinoma (RCC). Most of the therapeutic agents mediate cancer cell death through …

Redox homeostasis refers to the dynamic equilibrium between oxidant and reducing agent
in the body which plays a crucial role in maintaining normal physiological activities of the …

Radiotherapy is one of the most common modalities for the treatment of a wide range of
tumors, including colorectal cancer (CRC); however, radioresistance of cancer cells remains …

Abstract Chemoresistance to 5‐fluorouracil (5‐Fu)‐based chemotherapy is one of the
primary reasons for the failure of colorectal cancer (CRC) management. STAT3 can mediate …

Metal-derived platinum complexes are widely used to treat solid tumors. However, systemic
toxicity and tumor resistance to these drugs encourage further research into similarly …

In parallel with a steady rise in cancer incidence worldwide, the scientific community is
increasingly focused on finding novel, safer and more efficient modalities for managing this …

Cancer stem cells are found in many cancer types. They comprise a distinct subpopulation
of cells within the tumor that exhibit properties of stem cells. They express a number of cell …

Drug resistance continues to be a significant problem in cancer therapy, leading to relapse
and associated mortality. Although substantial progress has been made in understanding …