CRISPR‐Based KCC2 Upregulation Attenuates Drug‐Resistant Seizure in Mouse Models of Epilepsy
J Shi, H Xin, Y Shao, S Dai, N Tan, Z Li… - Annals of …, 2023 - Wiley Online Library
Objective The precise intervention of K‐Cl cotransporter isoform 2 (KCC2) as a promising
target for drug‐resistant epilepsy remains elusive. Methods Here, we used a CRISPRa …
target for drug‐resistant epilepsy remains elusive. Methods Here, we used a CRISPRa …
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits
L Chen, Y Xu, H Cheng, Z Li, N Lai, M Li… - … and Targeted Therapy, 2023 - nature.com
Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is
accompanied with altered adult-born dentate granule cells (abDGCs). However, the causal …
accompanied with altered adult-born dentate granule cells (abDGCs). However, the causal …