Sialic acid, the secret gift for the brain

F Liu, AB Simpson, E D'Costa, FS Bunn… - Critical Reviews in …, 2023 - Taylor & Francis
The human brain grows rapidly in early life which requires adequate nutrition. Human milk
provides optimal nutrition for the developing brain, and breastfeeding significantly improves …

Growing impact of sialic acid-containing glycans in future drug discovery

P Bose, MK Jaiswal, SK Singh, RK Singh… - Carbohydrate …, 2023 - Elsevier
In nature, almost all cells are covered with a complex array of glycan chain namely sialic
acids or nuraminic acids, a negatively charged nine carbon sugars which is considered for …

Selective PPAR-Delta/PPAR-gamma activation improves cognition in a model of Alzheimer's disease

I Steinke, M Govindarajulu, PD Pinky, J Bloemer, S Yoo… - Cells, 2023 - mdpi.com
Background: The continuously increasing association of Alzheimer's disease (AD) with
increased mortality rates indicates an unmet medical need and the critical need for …

[HTML][HTML] Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments

H Varbanov, S Jia, G Kochlamazashvili… - Neurobiology of …, 2023 - Elsevier
Dysregulated cortical expression of the neural cell adhesion molecule (NCAM) and deficits
of its associated polysialic acid (polySia) have been found in Alzheimer's disease and …

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

MA Minaya, S Mahali, AK Iyer, AM Eteleeb… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of
frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic …

Veränderungen der peritubulären Muskulatur im Hoden bei Polysialyltransferase-defizienten Mäusen

NE Hachem - 2023 - jlupub.ub.uni-giessen.de
In Strukturen des männlichen Reproduktionstraktes kommen Polysialylierungen während
der fetalen und postnatalen Entwicklung vor und beeinflussen diese. Die primär aus unserer …

Bioactive molecules in mother's milk and infant formula

F Liu - 2023 - research.rug.nl
Human milk is the optimal nutrition for infants. Human milk not only provides abundant
nutrients, it also contains non-nutritional bioactive components, like human milk …