RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

In recent decades, obesity has extensively emerged to the level of pandemics. It's
significantly associated with serious co-morbidities that could decrease life quality and even …

Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

RNA‐based therapeutics have the potential to revolutionize the treatment and prevention of
human diseases. While early research faced setbacks, it established the basis for …

Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA
biology has expanded substantially. miRNAs are involved and described as master …

Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary
brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization …

Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-
miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated …

MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the
post-transcriptional regulation of gene expression. They have been implicated in the …

Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific
cellular membrane structures. Cholesterol is involved in numerous cellular processes …

Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators
of many crucial cellular processes, and their dysregulation have been shown to contribute to …