Transcription factor mce3R modulates antibiotics and disease persistence in Mycobacterium tuberculosis

M Pandey, S Talwar, R Pal, V Nain, S Johri… - Research in …, 2023 - Elsevier
Abstract Transcription factors (TFs) of Mycobacterium tuberculosis (Mtb), an etiological agent
of tuberculosis, regulate a network of pathways that help prolong the survival of Mtb inside …

The Mycobacterium tuberculosis protein O-phosphorylation landscape

A Frando, V Boradia, M Gritsenko, C Beltejar… - Nature …, 2023 - nature.com
Bacterial phosphosignalling has been synonymous with two-component systems and their
histidine kinases, but many bacteria, including Mycobacterium tuberculosis (Mtb), also code …

[HTML][HTML] DNA structural properties of DNA binding sites for 21 transcription factors in the mycobacterial genome

U Dey, K Olymon, A Banik, E Abbas… - Frontiers in Cellular …, 2023 - frontiersin.org
Mycobacterium tuberculosis, the causative agent of tuberculosis, has evolved over time into
a multidrug resistance strain that poses a serious global pandemic health threat. The ability …

Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics

DX Zhu, CL Stallings - Journal of Biological Chemistry, 2023 - ASBMB
Bacterial pathogens like Mycobacterium tuberculosis (Mtb) employ transcription factors to
adapt their physiology to the diverse environments within their host. CarD is a conserved …

ResR/McdR-regulated protein translation machinery contributes to drug resilience in Mycobacterium tuberculosis

P Pal, MY Khan, S Sharma, Y Kumar, N Mangla… - Communications …, 2023 - nature.com
Survival response of the human tuberculosis pathogen, Mycobacterium tuberculosis (Mtb) to
a diverse environmental cues is governed through its versatile transcription regulatory …

[PDF][PDF] MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance

EJR Peterson, AN Brooks, DJ Reiss, A Kaur, J Do… - Cell Reports, 2023 - cell.com
The success of Mycobacterium tuberculosis (Mtb) is largely attributed to its ability to
physiologically adapt and withstand diverse localized stresses within host …

Bayesian Spiked Laplacian Graphs

LL Duan, G Michailidis, M Ding - Journal of Machine Learning Research, 2023 - jmlr.org
In network analysis, it is common to work with a collection of graphs that exhibit
heterogeneity. For example, neuroimaging data from patient cohorts are increasingly …

Mycobacterium tuberculosis Rv0494 Protein Contributes to Mycobacterial Persistence

L Ji, T Jiang, X Zhao, D Cai, K Hua, P Du… - Infection and Drug …, 2023 - Taylor & Francis
Purpose Fatty acid metabolism plays an important role in the survival and pathogenesis of
Mycobacterium tuberculosis. During dormancy, lipids are considered to be the main source …

Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

S Shee, RT Veetil, K Mohanraj, M Das, N Malhotra… - Elife, 2023 - elifesciences.org
Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive
oxygen species (ROS) but shows vulnerability to an increase in endogenous ROS (eROS) …

Mycobacterium tuberculosis transcriptional regulator Rv1019 is upregulated in hypoxia, and negatively regulates Rv3230c‐Rv3229c operon encoding enzymes in …

AR Pushparajan, LK Edison, R Ajay Kumar - The FEBS Journal, 2023 - Wiley Online Library
The main obstacle in eradicating tuberculosis is the ability of Mycobacterium tuberculosis to
remain dormant in the host, and then to get reactivated even years later under …