[HTML][HTML] Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

V Subramaniyan, NSA Lubau, N Mukerjee… - Toxicology Reports, 2023 - Elsevier
Confronting the profound public health concern of alcohol-induced liver damage calls for
inventive therapeutic measures. The social, economic, and clinical ramifications are …

[HTML][HTML] Antiaging effects of dietary supplements and natural products

L Gao, X Liu, X Luo, X Lou, P Li, X Li… - Frontiers in Pharmacology, 2023 - frontiersin.org
Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the
rapid social and economic development in recent decades, the proportion of the elderly has …

[HTML][HTML] Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer's disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 …

HH Awad, MA Desouky, A Zidan, M Bassem… - …, 2023 - Springer
Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark of many
neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant …

[HTML][HTML] Combination of epigallocatechin 3 gallate and curcumin improves d-galactose and normal-aging associated memory impairment in mice

MA Rahman, AA Shuvo, MMH Apu, MR Bhakta… - Scientific Reports, 2023 - nature.com
Previously, we observed curcumin improves aging-associated memory impairment in d-
galactose (D-gal) and normal-aged (NA) mice. Evidence showed that multiple agents can be …

Nuclear factor erythrogen-2 associated factor 2 (Nrf2) signaling is an essential molecular pathway for the anti-aging effect of whey protein in the prefrontal cortex of …

NR Sarhan, EM El Nashar, E Hamza, SM El-Beah… - Tissue and Cell, 2023 - Elsevier
Aging is a highly complicated natural process. Brain aging is associated with remarkable
neurodegenerative changes and oxidative damage. Whey protein (WP) has been …

Recent Advances in Computational Modeling of BACE1 Inhibitors as Anti-Alzheimer Agents

KD Papavasileiou, F Dondero, G Melagraki… - … Modeling of Drugs …, 2023 - Springer
A growing number of people worldwide are being affected by aging-associated
neurodegenerative illnesses, the most prevalent of which, Alzheimer's, is defined by …

A computational study to target necroptosis via RIPK1 inhibition

AK Bepari, H Takebayashi, JN Namme… - Journal of …, 2023 - Taylor & Francis
The human receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a critical
necroptosis regulator implicated in cancer, psoriasis, ulcerative colitis, rheumatoid arthritis …