Advances in soft mist inhalers
ABSTRACT Introduction Soft mist inhalers (SMIs) are propellant-free inhalers that utilize
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …
Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
[HTML][HTML] Air-liquid interface (ALI) impact on different respiratory cell cultures
The intranasal route has been receiving greater attention from the scientific community not
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
Aerosol pulmonary immune engineering
ER Sudduth, M Trautmann-Rodriguez, N Gill… - Advanced Drug Delivery …, 2023 - Elsevier
Aerosolization of immunotherapies poses incredible potential for manipulating the local
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …
Inhalable nanoparticle-based dry powder formulations for respiratory diseases: challenges and strategies for translational research
The emergence of novel respiratory infections (eg, COVID-19) and expeditious development
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …
Liposomes or extracellular vesicles: a comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery
The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention
compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and …
compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and …
Inhalation drug delivery in combating pulmonary infections: Advances and challenges
Pulmonary infections (PIs) are contributing as a significant cause of mortality across the
world. The clinical applications of a variety of therapeutics approved for PIs have been …
world. The clinical applications of a variety of therapeutics approved for PIs have been …
Challenges and strategies to enhance the systemic absorption of inhaled peptides and proteins
L Qin, Z Cui, Y Wu, H Wang, X Zhang, J Guan… - Pharmaceutical …, 2023 - Springer
Proteins and peptides-based therapeutics are making substantial access to the market due
to their obvious advantages of strong potency, high specificity and desirable safety profile …
to their obvious advantages of strong potency, high specificity and desirable safety profile …
Inhalable neutralizing antibodies–promising approach to combating respiratory viral infections
Monoclonal antibodies represent an exciting class of therapeutics against respiratory viral
infections. Notwithstanding their specificity and affinity, the conventional parenteral …
infections. Notwithstanding their specificity and affinity, the conventional parenteral …
Inhaled drug delivery for the targeted treatment of asthma
Asthma is a chronic lung disease affecting millions worldwide. While classically
acknowledged to result from allergen-driven type 2 inflammatory responses leading to IgE …
acknowledged to result from allergen-driven type 2 inflammatory responses leading to IgE …