PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …

Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

PURPOSE We present 5-year results from CheckMate 227 Part 1, in which nivolumab plus
ipilimumab improved overall survival (OS) versus chemotherapy in patients with metastatic …

Improved identification of anti-tumor T cells is needed to advance cancer immunotherapies.
CD39 expression is a promising surrogate of tumor-reactive CD8+ T cells. Here, we …

Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …

CUP accounts for< 5% of cancers but, because of its high mortality rate, its relative
contribution to cancer deaths is higher. 1 The incidence of CUP has been declining …

The limited efficacy of immunotherapies against glioblastoma underscores the urgency of
better understanding immunity in the central nervous system. We found that treatment with …

Importance There are few studies assessing the association of tumor mutational burden
(TMB) and clinical outcomes in a large cohort of patients with diverse advanced cancers …

Although pembrolizumab confers clinical benefit in non-small cell lung cancer (NSCLC),
only a subset of patients will respond due to a heterogenous tumor microenvironment …

Abstract RNA-sequencing (RNA-seq) has become an increasingly cost-effective technique
for molecular profiling and immune characterization of tumors. In the past decade, many …